Literature summary extracted from

Yang, Y.M.; Noureddin, M.; Liu, C.; Ohashi, K.; Kim, S.Y.; Ramnath, D.; Powell, E.E.; Sweet, M.J.; Roh, Y.S.; Hsin, I.F.; Deng, N.; Liu, Z.; Liang, J.; Mena, E.; Shouhed, D.; Schwabe, R.F.; Jiang, D.; Lu, S.C.; Noble, P.W.; Seki, E.
Hyaluronan synthase 2-mediated hyaluronan production mediates Notch1 activation and liver fibrosis (2019), Sci. Transl. Med., 11, eaat9284 .

Application

EC Number	Application	Comment	Organism
2.4.1.212	drug development	the enzyme actively synthesizes hyaluronan in hepatic stellate cells and promotes hepatic stellate cells activation and liver fibrosis through Notch1. Targeted hyaluronan inhibition may have potential to be an effective therapy for liver fibrosis	Homo sapiens
2.4.1.212	drug development	the enzyme actively synthesizes hyaluronan in hepatic stellate cells and promotes hepatic stellate cells activation and liver fibrosis through Notch1. Targeted hyaluronan inhibition may have potential to be an effective therapy for liver fibrosis	Mus musculus

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.4.1.212	Homo sapiens	Q92819	-	-
2.4.1.212	Mus musculus	P70312	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
2.4.1.212	hepatic stellate cell	-	Homo sapiens	-
2.4.1.212	hepatic stellate cell	-	Mus musculus	-

Synonyms

EC Number	Synonyms	Comment	Organism
2.4.1.212	Has2	-	Homo sapiens
2.4.1.212	Has2	-	Mus musculus
2.4.1.212	hyaluronan synthase 2	-	Homo sapiens
2.4.1.212	hyaluronan synthase 2	-	Mus musculus

Expression

EC Number	Organism	Comment	Expression
2.4.1.212	Homo sapiens	hyaluronan synthase 2 expression is elevated in both human and murine liver fibrosis. The enzyme is transcriptionally up-regulated by transforming growth factor-beta through Wilms tumor 1 to promote fibrogenic, proliferative, and invasive properties of HSCs via CD44, Toll-like receptor 4, and newly identified downstream effector Notch1	up
2.4.1.212	Mus musculus	hyaluronan synthase 2 expression is elevated in both human and murine liver fibrosis. The enzyme is transcriptionally up-regulated by transforming growth factor-beta through Wilms tumor 1 to promote fibrogenic, proliferative, and invasive properties of HSCs via CD44, Toll-like receptor 4, and newly identified downstream effector Notch1	up

General Information

EC Number	General Information	Comment	Organism
2.4.1.212	metabolism	hyaluronan synthase 2 expression is elevated in both human and murine liver fibrosis. The enzyme actively synthesizes hyaluronan in hepatic stellate cells and promotes activation of hepatic stellate cells and liver fibrosis through Notch1	Homo sapiens
2.4.1.212	metabolism	hyaluronan synthase 2 expression is elevated in both human and murine liver fibrosis. The enzyme actively synthesizes hyaluronan in hepatic stellate cells and promotes activation of hepatic stellate cells and liver fibrosis through Notch1	Mus musculus

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)